The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates
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چکیده
منابع مشابه
The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates.
A longevity gene called Indy (for 'I'm not dead yet'), with similarity to mammalian genes encoding sodium-dicarboxylate cotransporters, was identified in Drosophila melanogaster. Functional studies in Xenopus oocytes showed that INDY mediates the flux of dicarboxylates and citrate across the plasma membrane, but the specific transport mechanism mediated by INDY was not identified. To test wheth...
متن کاملSodium-coupled transporters for Krebs cycle intermediates.
Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate are transferred across plasma membranes of cells by secondary active transporters that couple the downhill movement of sodium to the concentrative uptake of substrate. Several transporters have been identified in isolated membrane vesicles and cells based on their functional properties, suggesting the existence of at ...
متن کاملFunctional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy.
Caloric restriction extends life span in a variety of species, highlighting the importance of energy balance in aging. A new longevity gene, Indy (for I'm not dead yet), which doubles the average life span of flies without a loss of fertility or physical activity, was postulated to extend life by affecting intermediary metabolism. We report that functional studies in Xenopus oocytes show INDY i...
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15 صفحه اولEffect of streptolysin O on the utilization of some Krebs cycle intermediates by Aerobacter aerogenes.
A preparation of streptolysin 0 partially purified from Streptococcus pyogenes strain C203S was shown to contain at least two distinct entities (Carlson et al., 1956): streptolysin 0 which brings about a marked loss of myocardial contractile power in isolated, perfused guinea pig, rabbit, and rat hearts (Kellner et al., 1956), and a diphosphopyridine nucleotidase which specifically attacks diph...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2006
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20060409