The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates.

A longevity gene called Indy (for 'I'm not dead yet'), with similarity to mammalian genes encoding sodium-dicarboxylate cotransporters, was identified in Drosophila melanogaster. Functional studies in Xenopus oocytes showed that INDY mediates the flux of dicarboxylates and citrate across the plasma membrane, but the specific transport mechanism mediated by INDY was not identified. To test wheth...

متن کامل

Sodium-coupled transporters for Krebs cycle intermediates.

Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate are transferred across plasma membranes of cells by secondary active transporters that couple the downhill movement of sodium to the concentrative uptake of substrate. Several transporters have been identified in isolated membrane vesicles and cells based on their functional properties, suggesting the existence of at ...

متن کامل

Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy.

Caloric restriction extends life span in a variety of species, highlighting the importance of energy balance in aging. A new longevity gene, Indy (for I'm not dead yet), which doubles the average life span of flies without a loss of fertility or physical activity, was postulated to extend life by affecting intermediary metabolism. We report that functional studies in Xenopus oocytes show INDY i...

متن کامل

“the effect of risk aversion on the demand for life insurance: the case of iranian life insurance market”

abstract: about 60% of total premium of insurance industry is pertained?to life policies in the world; while the life insurance total premium in iran is less than 6% of total premium in insurance industry in 2008 (sigma, no 3/2009). among the reasons that discourage the life insurance industry is the problem of adverse selection. adverse selection theory describes a situation where the inf...

15 صفحه اول

Effect of streptolysin O on the utilization of some Krebs cycle intermediates by Aerobacter aerogenes.

A preparation of streptolysin 0 partially purified from Streptococcus pyogenes strain C203S was shown to contain at least two distinct entities (Carlson et al., 1956): streptolysin 0 which brings about a marked loss of myocardial contractile power in isolated, perfused guinea pig, rabbit, and rat hearts (Kellner et al., 1956), and a diphosphopyridine nucleotidase which specifically attacks diph...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Biochemical Journal

سال: 2006

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj20060409